The module presents a review of the reactions of alkanes, alkenes, alkynes, etc focusing on their use in synthesis, the notion of functional group interconversion. Additionally the chemistry of carbonyl compounds - general reactions, nucleophilic addition, nucleophilic acyl substitution, alpha substitution and carbonyl condensation reactions including imines, hemiacetals and acetals. Oxidation and reduction of alcohols and carbonyls. Reactions primary, secondary and tertiary alkyl halides including SN1 and SN2 and E1 and E2 mechanisms.
Aromatic compounds - review structure and electrophilic substitution; extend to substituent effects on the rate and orientation. Consideration of approaches to the synthesis of common substituted benzenes, Effect of substituent groups on the basicity and acidity of aromatic amines, phenols and carboxylic acids. Applications of aromatic compounds in medicine, colour chemistry and explosives
An introduction to stereochemistry will be presented to include – enantiomerism(optical isomerism) of compounds with up to 2 different chiral centres. Rectus(R) and sinister(S) nomenclature. Diastereoisomerism including cis-trans isomerism. Zusammen(Z) and Entgegen(E) nomenclature. Boat and Chair conformations of cyclohexane derivatives, Newmann Projections.
The basic principles of IR and NMR spectroscopy and their use in the interpretation of the spectra of simple aliphatic and aromatic molecules will be covered.
This module will work to develop a number of the key 'I am UWS' Graduate Attributes. Those who complete this module will have developed competencies in report writing, working to deadlines and developing academic knowledge.
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